Nature Communications (May 2020)
The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair
- Qin Zhou,
- Jinzhou Huang,
- Chao Zhang,
- Fei Zhao,
- Wootae Kim,
- Xinyi Tu,
- Yong Zhang,
- Somaira Nowsheen,
- Qian Zhu,
- Min Deng,
- Yuping Chen,
- Bo Qin,
- Kuntian Luo,
- Baohua Liu,
- Zhenkun Lou,
- Robert W. Mutter,
- Jian Yuan
Affiliations
- Qin Zhou
- Department of Oncology, Mayo Clinic
- Jinzhou Huang
- Department of Oncology, Mayo Clinic
- Chao Zhang
- Department of Oncology, Mayo Clinic
- Fei Zhao
- Department of Oncology, Mayo Clinic
- Wootae Kim
- Department of Oncology, Mayo Clinic
- Xinyi Tu
- Department of Oncology, Mayo Clinic
- Yong Zhang
- Department of Oncology, Mayo Clinic
- Somaira Nowsheen
- Mayo Medical Scientist Training Program, Mayo Clinic School of Medicine and Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic
- Qian Zhu
- Research Center for Translational Medicine, East Hospital, Tongji University School of medicine
- Min Deng
- Department of Oncology, Mayo Clinic
- Yuping Chen
- Research Center for Translational Medicine, East Hospital, Tongji University School of medicine
- Bo Qin
- Department of Oncology, Mayo Clinic
- Kuntian Luo
- Department of Oncology, Mayo Clinic
- Baohua Liu
- Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Department of Biochemistry & Molecular Biology, School of Basic Medical Sciences, Shenzhen University Health Science Center
- Zhenkun Lou
- Department of Oncology, Mayo Clinic
- Robert W. Mutter
- Department of Radiation Oncology, Mayo Clinic
- Jian Yuan
- Research Center for Translational Medicine, East Hospital, Tongji University School of medicine
- DOI
- https://doi.org/10.1038/s41467-020-16443-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
The bromodomain containing protein BRD9 has been reported to regulate chromatin remodeling and transcription. Here the authors reveal a role for BRD9 in homologous recombination by facilitating RAD51–RAD54 interaction.
