Frontiers in Oncology (Feb 2019)

An Efficacious Endometrial Sampler for Screening Endometrial Cancer

  • Lu Han,
  • Lu Han,
  • Jiang Du,
  • Lanbo Zhao,
  • Chao Sun,
  • Chao Sun,
  • Qi Wang,
  • Qi Wang,
  • Xiaoqian Tuo,
  • Xiaoqian Tuo,
  • Huilian Hou,
  • Yu Liu,
  • Qing Wang,
  • Qing Wang,
  • Qurat Ulain,
  • Qurat Ulain,
  • Shulan Lv,
  • Guanjun Zhang,
  • Qing Song,
  • Qing Song,
  • Qiling Li,
  • Qiling Li

DOI
https://doi.org/10.3389/fonc.2019.00067
Journal volume & issue
Vol. 9

Abstract

Read online

Recently, the research on early detection of precancerous change and endometrial carcinoma has been focusing on minimally invasive procedures for screening. On this basis, we aim to verify the feasibility of endometrial samplers for screening endometrial cancer using Li Brush. We recruited patients undergoing hysterectomy for different diseases from the Inpatient Department of the Department of Obstetrics and Gynecology. Before surgery, endometrial cells were collected by Li Brush. The cytopathologic diagnosis from Li Brush and the histopathologic diagnosis from hysterectomy in the same patient were compared to calculate sensitivity (Se), specificity (Sp), false-negative rate (FNR), false-positive rate (FPR), positive predictive value (PV+) %, and negative predictive value (PV-). The research enrolled 293 women into this self-controlled trial. According to the hypothesis test of paired four lattices, we obtained the following indicators: Se 92.73, Sp 98.15, FNR 7.27, FPR 1.85, PV+92.73, and PV−98.15%. The endometrial sampler Li Brush is an efficacious instrument for screening endometrial cancer.

Keywords