Nature Communications (Nov 2020)

An enhanced isothermal amplification assay for viral detection

  • Jason Qian,
  • Sarah A. Boswell,
  • Christopher Chidley,
  • Zhi-xiang Lu,
  • Mary E. Pettit,
  • Benjamin L. Gaudio,
  • Jesse M. Fajnzylber,
  • Ryan T. Ingram,
  • Rebecca H. Ward,
  • Jonathan Z. Li,
  • Michael Springer

DOI
https://doi.org/10.1038/s41467-020-19258-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Current state-of-the-art diagnostics for infectious diseases are sensitive but require extensive equipment. Here the authors develop an enhanced recombinase polymerase amplification reaction for SARS-CoV-2 that allows for inexpensive and rapid testing with minimal equipment.