Clinical Interventions in Aging (Feb 2023)
Field-Based Estimates of Muscle Quality Index Determine Timed-Up-and-Go Test Performance in Obese Older Women
Abstract
Ivo Vieira de Sousa Neto,1 Joyce de Sousa Diniz,2 Vicente Paulo Alves,2 Alessandra Ribeiro Ventura Oliveira,2 Monica Palermo de Souza Barbosa,2 Carla Regina da Silva Prado,2 Jaqueline Alves Alencar,2 Karla Helena Coelho Vilaça e Silva,2 Cristiane Rocha Silva,3 Gleison Miguel Lissemerki Ferreira,3 Danielle Garcia,3 Roberto A Grisa,3 Jonato Prestes,3 Geiziane Leite Rodrigues Melo,3 Larissa Lauda Burmann,2 Fernanda Nelli Gomes Giuliani,2 Fabiani Lage Rodrigues Beal,2 Andréa Paula Severiano,2 Dahan da Cunha Nascimento3 1School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil; 2Department of Gerontology, Catholic University of Brasilia, UCB, Brasília, DF, Brazil; 3Department of Physical Education, Catholic University of Brasilia (UCB), Brasília, BrazilCorrespondence: Dahan da Cunha Nascimento, Programa de Pós-Graduação Stricto Sensu em Educação Física, Universidade Católica de Brasília – Q.S. 07, Lote 01, EPTC – Bloco G. Zip code: 71966-700 – Distrito Federal, Brasilia, Brazil, Tel/Fax +21/55/61 3356 9350, Email [email protected]: The muscle quality index (MQI) is associated with numerous health outcomes in adults; however, the effects of distinct MQI on functional capacity in obese older women have not yet been fully investigated. Thus, we investigated the contribution of different muscle quality indices on TUG performance prediction in obese older women. We secondarily evaluated the association between MQI, aerobic capacity performance (Treadmill performance and 6-minute walk test), and obesity indices (BMI, body fat percentage, and neck, waist, and hip circumference).Methods: Participants included 64 obese older women (mean age 67.05 ± 5.46 years, body fat ≥ 35%). General anthropometric, health history, body composition, treadmill exercise, and functional test (Time up and go) measures were collected. A hydraulic dynamometer was used to assess muscle strength, and Dual Energy X-ray Absorptiometry (DXA) to identify body fat percentage. The field MQI was defined as the highest reading divided by the subject’s body mass index (BMI), while the laboratory MQI was obtained by the ratio of grip strength to the entire arm muscle in kilograms measured by DXA. A hierarchical multiple regression was performed to predict TUG-test performance.Results: An increase in field MQI of one unit is associated with a decrease of 2.59 seconds in the TUG test (β = − 0.540; p = 0.004). There was no association between laboratory MQI and TUG performance (β = 0.067; p = 0.712). Furthermore, field MQI displays a positive correlation (p < 0.05) with aerobic capacity performance (6-minute walk test and peak O2 consumption) and a negative correlation (p < 0.05) with diverse obesity indices (neck and waist circumference, body fat, and BMI).Conclusion: MQI displayed an important prediction with TUG-test, a positive correlation with aerobic capacity, and a negative correlation with obesity indices.Keywords: muscle quality, aging, functional capacity, obesity, muscle mass, sarcopenia
