Detection of Sars-Cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis

Abstract

The clinical and laboratory findings of subacute thyroiditis hav e been repeatedly reported as being associated with acute Sars-Cov-2 infection and post-COVID-19 syndrome. The exact mechanisms and histopathological correlations underlying thyroid involvement remained unresolved, but current insights suggest either direct viral damage, systemic inflammatory reaction, or an autoi mmune response as possible noxious effectors. Here we present findings of immuno histochemical/ immunofluorescence detection of Sars-Cov-2 viral proteins (spike/S and nucleocapside proteins) in relation to histoarchitectonic changes of autoptic thyroid tissue obtained from patient who deceased from COVID-19.

Keywords

• sars-cov-2
• covid-19
• spike protein
• thyroid gland
• subacute thyroiditis