Planning in silico screening and experimental study of the hypoglycemic derivatives of cyclic guanidines

Abstract

This article is devoted to the search for new cyclic guanidine derivatives with hypoglycemic activity by means of in silico methods. The results of computer prediction of hypoglycemic effect for nine classes of these compounds were analyzed. Two perspective classes of cyclic guanidine derivatives have been identified. Planning in silico screening was performed and new unstudied substances were tested.

Keywords

• циклические гуанидины
• гипогликемическая активность
• методы in silico
• диабет
• компьютерное планирование экспериментов
• cyclic guanidines
• hypoglycemic activity
• in silico methods
• diabetes
• computer planning of experiments