Nature Communications (Mar 2018)
nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer
- Ji-Hye Ahn,
- Hyun-Sung Lee,
- Ju-Seog Lee,
- Yeon-Su Lee,
- Jong-Lyul Park,
- Seon-Young Kim,
- Jung-Ah Hwang,
- Nawapol Kunkeaw,
- Sung Yun Jung,
- Tae Jin Kim,
- Kwang-Soo Lee,
- Sung Ho Jeon,
- Inhan Lee,
- Betty H. Johnson,
- Jung-Hye Choi,
- Yong Sun Lee
Affiliations
- Ji-Hye Ahn
- Department of Life and Nanopharmaceutical Sciences and Department of Oriental Pharmaceutical Science, Kyung Hee University
- Hyun-Sung Lee
- Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine
- Ju-Seog Lee
- Department of Systems Biology, University of Texas MD Anderson Cancer Center
- Yeon-Su Lee
- Rare Cancer Branch, Research Institute, National Cancer Center
- Jong-Lyul Park
- Medical Genomics Research Center, KRIBB
- Seon-Young Kim
- Medical Genomics Research Center, KRIBB
- Jung-Ah Hwang
- Genomics Core Laboratory, Omics Core Laboratory, Research Institute, National Cancer Center
- Nawapol Kunkeaw
- Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
- Sung Yun Jung
- Verna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
- Tae Jin Kim
- Department of Obstetrics and Gynecology, Cheil General Hospital and Women’s Healthcare Center, College of Medicine Dankook University
- Kwang-Soo Lee
- Department of Life Science and Center for Aging and Health Care, Hallym University
- Sung Ho Jeon
- Department of Life Science and Center for Aging and Health Care, Hallym University
- Inhan Lee
- miRcore
- Betty H. Johnson
- Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
- Jung-Hye Choi
- Department of Life and Nanopharmaceutical Sciences and Department of Oriental Pharmaceutical Science, Kyung Hee University
- Yong Sun Lee
- Department of Biochemistry and Molecular Biology, University of Texas Medical Branch
- DOI
- https://doi.org/10.1038/s41467-018-03556-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Ovarian cancers often display elevated TGF-β signaling but repressed miRNA expression. Here the authors identify that non-coding RNA nc886 expression is induced by TGF-β, which then binds to DICER and impairs miRNA maturation.
