Associations of Menstrual Cycle Regularity and Length With Cardiovascular Diseases: A Prospective Study From UK Biobank

Chensihan Huang; Bingquan Lin; Youwen Yuan; Kangli Li; Bingyan Xu; Peizhen Zhang; Xueyun Wei; Weiwei Wang; Wenhui Liu; Yajuan Deng; Deying Liu; Jiayang Lin; Yan Huang; Huijie Zhang

doi:10.1161/JAHA.122.029020

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease (Jun 2023)

Associations of Menstrual Cycle Regularity and Length With Cardiovascular Diseases: A Prospective Study From UK Biobank

Chensihan Huang,
Bingquan Lin,
Youwen Yuan,
Kangli Li,
Bingyan Xu,
Peizhen Zhang,
Xueyun Wei,
Weiwei Wang,
Wenhui Liu,
Yajuan Deng,
Deying Liu,
Jiayang Lin,
Yan Huang,
Huijie Zhang

Affiliations

Chensihan Huang: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Bingquan Lin: Imaging Center, Nanfang Hospital Southern Medical University Guangzhou China
Youwen Yuan: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Kangli Li: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Bingyan Xu: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Peizhen Zhang: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Xueyun Wei: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Weiwei Wang: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Wenhui Liu: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Yajuan Deng: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Deying Liu: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Jiayang Lin: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Yan Huang: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China
Huijie Zhang: Department of Endocrinology and Metabolism, Nanfang Hospital Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation, State Key Laboratory of Organ Failure Research Guangzhou China

DOI: https://doi.org/10.1161/JAHA.122.029020
Journal volume & issue: Vol. 12, no. 11

Abstract

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Background The association between menstrual cycle characteristics and cardiovascular outcomes remains unclear. This study was undertaken to evaluate whether menstrual cycle regularity and length throughout the life course are associated with cardiovascular outcomes. Methods and Results This cohort study included 58 056 women who had no cardiovascular disease (CVD) at baseline and reported their menstrual cycle regularity and length. Hazard ratios (HRs) and 95% CIs for CVD events were estimated using Cox proportional hazards models. During the median 11.8 years of follow‐up, 1623 incident CVD cases were documented, including 827 incident cases of coronary heart disease, 199 myocardial infarctions, 271 strokes, 174 cases of heart failure, and 393 cases of atrial fibrillations. Compared with women with regular menstrual cycles, the HRs for women with irregular menstrual cycles were 1.19 (95% CI, 1.07–1.31) for CVD events and 1.40 (95% CI, 1.14–1.72) for atrial fibrillation. The multivariable‐adjusted HRs for short (≤21 days) or long (35 days) menstrual cycles during follow‐up were 1.29 (95% CI, 1.11–1.50) and 1.11 (95% CI, 0.98–1.56) for CVD events, respectively. Similarly, long or short cycle length were more likely to be associated with increased risk of atrial fibrillation (HR, 1.30 [95% CI, 1.01–1.66]; and HR, 1.38 [95% CI, 1.02–1.87]), and short cycle length was more likely to be associated with increased risk of coronary heart disease and myocardial infarction. However, these associations for stroke and heart failure were not significant. Conclusions Long or short menstrual cycle length was associated with increased risks of CVD and atrial fibrillation but not myocardial infarction, heart failure, or stroke. Short cycle length was associated with a greater risk of coronary heart disease and myocardial infarction.

Published in Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

ISSN: 2047-9980 (Online)
Publisher: Wiley
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.ahajournals.org/journal/jaha

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