Synthetic and Systems Biotechnology (Mar 2020)
Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production
Abstract
Overproduction of polyketides has been a challenge for metabolic engineering for decades. However, recent studies have demonstrated that in both native host and heterologous host, engineering β -oxidation pathways can lead to dramatic improvement of polyketide production. Keywords: Polyketide, Beta-oxidation pathway, Metabolic engineering, Triacylglycerols