Nature Communications (May 2019)

A redox-neutral synthesis of ketones by coupling of alkenes and amides

  • Jing Li,
  • Rik Oost,
  • Boris Maryasin,
  • Leticia González,
  • Nuno Maulide

DOI
https://doi.org/10.1038/s41467-019-10151-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 7

Abstract

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Classical hydroacylation of alkenes with aldehydes is a straightforward route to ketones, however aldehyde decarbonylation is a common side-process. Here, the authors report the coupling of amides, as hydroacylating agents, and alkenes under mild, metal-free conditions to afford a wide range of ketones.