Nature Communications (May 2019)
A redox-neutral synthesis of ketones by coupling of alkenes and amides
Abstract
Classical hydroacylation of alkenes with aldehydes is a straightforward route to ketones, however aldehyde decarbonylation is a common side-process. Here, the authors report the coupling of amides, as hydroacylating agents, and alkenes under mild, metal-free conditions to afford a wide range of ketones.