A Nanoscale Cobalt Functionalized Strandberg-Type Phosphomolybdate with <i>β</i>-Sheet Conformation Modulation Ability in Anti-Amyloid Protein Misfolding
Man Wang,
Jiai Hua,
Pei Zheng,
Yuanzhi Tian,
Shaodan Kang,
Junjun Chen,
Yifan Duan,
Xiang Ma
Affiliations
Man Wang
Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China
Jiai Hua
Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China
Pei Zheng
Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China
Yuanzhi Tian
Laboratory of Biochemistry and Pharmacy, Taiyuan Institute of Technology, Taiyuan 030008, China
Shaodan Kang
Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China
Junjun Chen
Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China
Yifan Duan
Laboratory of Biochemistry and Pharmacy, Taiyuan Institute of Technology, Taiyuan 030008, China
Xiang Ma
Chemistry and Chemical Engineering Department, Taiyuan Institute of Technology, Taiyuan 030008, China
For decades, amyloid β-peptide (Aβ) misfolding aggregates with β-sheet structures have been linked to the occurrence and advancement of Alzheimer’s disease (AD) development and progression. As a result, modulating the misfolding mode of Aβ has been regarded as an important anti-amyloid protein misfolding strategy. A polyoxometalate based on {Co(H2O)4}2+ complex and [P2Mo5O23]6− fragments, K8{[Co(H2O)4][HP2Mo5O23]2}·8H2O (abbreviated as CoPM), has been synthesized and structurally characterized using elemental analysis, single-crystal X-ray diffraction (SXRD), IR, UV spectra, bond valence sums (Σs) calculation, and powder XRD (PXRD). CoPM’s primary component, as revealed by structural analysis, is a nanoscale polyoxoanion made of [Co(H2O)4]2+ sandwiched between two [P2Mo5O23]6− pieces. Notably, it is demonstrated that CoPM efficiently modulates Aβ aggregates’ β-sheet-rich conformation.
