Role and Mechanism of SLAMF7-SLAMF7 Signaling Pathway in Tumor Progression

Abstract

The signaling lymphocytes activating molecule factor 7(SLAMF7) is not only expressed on the surface of some malignant tumor cells, but also widely expressed in immune cells, including natural killer cells, CD4+T cells, CD8+T cells, B cells, dendritic cells (DCs) and monocytes/macrophages. It can regulate the biological behavior of tumor cells as well as immune cells and contribute to anti-tumor effects of immune cells in tumor microenvironment. Herein, we review the functional role of SLAMF7 in regulating immune cells to suppress tumor progression.

Keywords

• slamf7
• immune regulation
• multiple myeloma
• elotuzumab