Extensive gut virome variation and its associations with host and environmental factors in a population-level cohort

Suguru Nishijima; Naoyoshi Nagata; Yuya Kiguchi; Yasushi Kojima; Tohru Miyoshi-Akiyama; Moto Kimura; Mitsuru Ohsugi; Kohjiro Ueki; Shinichi Oka; Masashi Mizokami; Takao Itoi; Takashi Kawai; Naomi Uemura; Masahira Hattori

doi:10.1038/s41467-022-32832-w

Nature Communications (Sep 2022)

Extensive gut virome variation and its associations with host and environmental factors in a population-level cohort

Suguru Nishijima,
Naoyoshi Nagata,
Yuya Kiguchi,
Yasushi Kojima,
Tohru Miyoshi-Akiyama,
Moto Kimura,
Mitsuru Ohsugi,
Kohjiro Ueki,
Shinichi Oka,
Masashi Mizokami,
Takao Itoi,
Takashi Kawai,
Naomi Uemura,
Masahira Hattori

Affiliations

Suguru Nishijima: Graduate School of Advanced Science and Engineering, Waseda University
Naoyoshi Nagata: Department of Gastroenterological Endoscopy, Tokyo Medical University
Yuya Kiguchi: Graduate School of Advanced Science and Engineering, Waseda University
Yasushi Kojima: Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine
Tohru Miyoshi-Akiyama: Pathogenic Microbe Laboratory, Research Institute, National Center for Global Health and Medicine
Moto Kimura: Department of Clinical Research Strategic Planning Center for Clinical Sciences, National Center for Global Health and Medicine
Mitsuru Ohsugi: Department of Diabetes, Endocrinology, and Metabolism, Center Hospital, National Center for Global Health and Medicine
Kohjiro Ueki: Diabetes Research Center, Research Institute, National Center for Global Health and Medicine
Shinichi Oka: AIDS Clinical Center, National Center for Global Health and Medicine Hospital
Masashi Mizokami: Genome Medical Sciences Project, Research Institute, National Center for Global Health and Medicine
Takao Itoi: Department of Gastroenterology and Hepatology, Tokyo Medical University
Takashi Kawai: Department of Gastroenterological Endoscopy, Tokyo Medical University
Naomi Uemura: Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Kohnodai Hospital
Masahira Hattori: Graduate School of Advanced Science and Engineering, Waseda University

DOI: https://doi.org/10.1038/s41467-022-32832-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Here, Nishijima et al. perform a large-scale analysis of the human gut virome in the Japanese 4D cohort of 4198 deeply phenotyped individuals, revealing thousands of bacteriophage genomes, virus-bacteria interactions, and describing associations with various host and environmental factors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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