BMJ Open (Feb 2021)
Cross-sectional observational study of epidemiology of COVID-19 and clinical outcomes of hospitalised patients in North West London during March and April 2020
- ,
- Charlotte Anderson,
- Paula Blomquist,
- Rohini Manuel,
- Ayesha Akbar,
- Katherine Adams,
- Ashley Whittington,
- Miriam Harris,
- Alastair McGregor,
- Padmasayee Papineni,
- Guduru Gopal Rao,
- Alexander Allen,
- Liyang Wang,
- Laurence John,
- Stephen Hiles,
- Thomas Nicholas,
- Valerie Decraene,
- Bharat Patel,
- Yimmy Chow,
- Martin Kuper,
- Sharpe Roger,
- Cohen David,
- Tennant Rachel,
- Vaid Nidhi,
- Sahnan Kapil,
- Gross Jamie,
- Husain Tariq,
- Parris Victoria,
- Sandhu Gurjinder,
- Rosen Stuart,
- Cayley Charles,
- Patel Sangita,
- Blair Mitchel,
- Lewis Simon,
- Chita Sunder,
- Winn Trish,
- Biggin-Lamming James,
- Sewel Catherine,
- Gregory Laila,
- Tozer Philip,
- Littler Stephen
Affiliations
- 4Association of British Neurologists
- Charlotte Anderson
- 2 Concussion Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada
- Paula Blomquist
- 1 Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections at University College London, in partnership with Public Health England and in collaboration with London School of Hygiene & Tropical Medicine, National Institute for Health Research, London, UK
- Rohini Manuel
- consultant microbiologist
- Ayesha Akbar
- St Mark`s Hospital, Harrow, UK
- Katherine Adams
- Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK
- Ashley Whittington
- Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK
- Miriam Harris
- Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK
- Alastair McGregor
- Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK
- Padmasayee Papineni
- consultant in infectious diseases and acute medicine
- Guduru Gopal Rao
- Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK
- Alexander Allen
- London
- Liyang Wang
- Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK
- Laurence John
- Department of Infectious Diseases, Northwick Park Hospital, London North West University Healthcare NHS Trust, Harrow, UK
- Stephen Hiles
- Swansea Trials Unit (STU), Swansea University, Swansea, West Glamorgan, UK
- Thomas Nicholas
- Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK
- Valerie Decraene
- Field Epidemiology and Health Protection Units, Public Health England, London, UK
- Bharat Patel
- Rushall Medical Centre, Walsall, UK
- Yimmy Chow
- Field Epidemiology and Health Protection Units, Public Health England, London, UK
- Martin Kuper
- Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK
- Sharpe Roger
- Cohen David
- Tennant Rachel
- Vaid Nidhi
- Sahnan Kapil
- Gross Jamie
- Husain Tariq
- Parris Victoria
- Sandhu Gurjinder
- Rosen Stuart
- Cayley Charles
- Patel Sangita
- Blair Mitchel
- Lewis Simon
- Chita Sunder
- Winn Trish
- Biggin-Lamming James
- Sewel Catherine
- Gregory Laila
- Tozer Philip
- Littler Stephen
- DOI
- https://doi.org/10.1136/bmjopen-2020-044384
- Journal volume & issue
-
Vol. 11,
no. 2
Abstract
Objective The aim of this paper is to describe evolution, epidemiology and clinical outcomes of COVID-19 in subjects tested at or admitted to hospitals in North West London.Design Observational cohort study.Setting London North West Healthcare NHS Trust (LNWH).Participants Patients tested and/or admitted for COVID-19 at LNWH during March and April 2020Main outcome measures Descriptive and analytical epidemiology of demographic and clinical outcomes (intensive care unit (ICU) admission, mechanical ventilation and mortality) of those who tested positive for COVID-19.Results The outbreak began in the first week of March 2020 and reached a peak by the end of March and first week of April. In the study period, 6183 tests were performed in on 4981 people. Of the 2086 laboratory confirmed COVID-19 cases, 1901 were admitted to hospital. Older age group, men and those of black or Asian minority ethnic (BAME) group were predominantly affected (p<0.05). These groups also had more severe infection resulting in ICU admission and need for mechanical ventilation (p<0.05). However, in a multivariate analysis, only increasing age was independently associated with increased risk of death (p<0.05). Mortality rate was 26.9% in hospitalised patients.Conclusion The findings confirm that men, BAME and older population were most commonly and severely affected groups. Only older age was independently associated with mortality.
