The Utilization of Body Composition to Predict Cardiorespiratory Fitness and Determine Association with CKD Stage in Individuals with Mid-Spectrum CKD: A Pilot Study

Jeffrey S. Forsse; Kathleen A. Richardson; Tomas J. Chapman-Lopez; Ricardo Torres; Jeffery L. Heileson; Ahmed Ismaeel; LesLee Funderburk; Andrew R. Gallucci; Dale C. Allison; Panagiotis Koutakis

doi:10.3390/kidneydial3030024

Kidney and Dialysis (Aug 2023)

The Utilization of Body Composition to Predict Cardiorespiratory Fitness and Determine Association with CKD Stage in Individuals with Mid-Spectrum CKD: A Pilot Study

Jeffrey S. Forsse,
Kathleen A. Richardson,
Tomas J. Chapman-Lopez,
Ricardo Torres,
Jeffery L. Heileson,
Ahmed Ismaeel,
LesLee Funderburk,
Andrew R. Gallucci,
Dale C. Allison,
Panagiotis Koutakis

Affiliations

Jeffrey S. Forsse: Integrated Laboratory of Exercise, Nutrition, and Renal Vascular Research, Department of Health Human Performance and Recreation, Baylor University, Waco, TX 76706, USA
Kathleen A. Richardson: Integrated Laboratory of Exercise, Nutrition, and Renal Vascular Research, Department of Health Human Performance and Recreation, Baylor University, Waco, TX 76706, USA
Tomas J. Chapman-Lopez: Integrated Laboratory of Exercise, Nutrition, and Renal Vascular Research, Department of Health Human Performance and Recreation, Baylor University, Waco, TX 76706, USA
Ricardo Torres: Integrated Laboratory of Exercise, Nutrition, and Renal Vascular Research, Department of Health Human Performance and Recreation, Baylor University, Waco, TX 76706, USA
Jeffery L. Heileson: Walter Reed Army Medical Center, Bethesda, MD 20814, USA
Ahmed Ismaeel: Clinical Muscle Biology Lab, Biology Department, Baylor University, Waco, TX 76798, USA
LesLee Funderburk: Human Sciences and Design, Baylor University, Waco, TX 76798, USA
Andrew R. Gallucci: Integrated Laboratory of Exercise, Nutrition, and Renal Vascular Research, Department of Health Human Performance and Recreation, Baylor University, Waco, TX 76706, USA
Dale C. Allison: Baylor Scott & White Health, Waco, TX 76712, USA
Panagiotis Koutakis: Clinical Muscle Biology Lab, Biology Department, Baylor University, Waco, TX 76798, USA

DOI: https://doi.org/10.3390/kidneydial3030024
Journal volume & issue: Vol. 3, no. 3
pp. 265 – 273

Abstract

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Body composition (BC), a measure of body fat mass (FM), lean body mass (LBM), and bone mineral content (BMC), can be used as a predictor of cardiorespiratory fitness (CRF). Prior studies have established a relationship between BC and VO2max in healthy individuals over 35 years of age. However, this relationship is poorly understood in chronic disease populations. The focus of the study was to assess the relationship between BC, cardiorespiratory fitness, and chronic kidney disease (CKD). A cross-sectional analysis was conducted among 24 (9 males and 15 females) individuals diagnosed with mid-spectrum CKD (stages G2–G3b) who completed a health screening, dual-energy X-ray absorptiometry (DEXA) scan, and underwent a VO2max exercise test. Normality tests, descriptive statistics, Pearson’s correlations, t-tests, and ANOVAs were conducted in SAS v.9.4. The average percent body fat (%BF) was 36.28 ± 8.47%, LBM was 109.4 ± 29.1 lb, BMC was 2308.7 ± 735.1 g, and VO2max was 20.13 ± 5.04 mL/kg/min−1. BC was able to predict CRF via VO2max (R2 = 0.721, p p p p p p 2max, and CKD stage. The progression of the CKD stage was associated with lower LBM, BMC, and VO2max values, indicating a graded effect of BC on CRF and CKD stage.

Published in Kidney and Dialysis

ISSN: 2673-8236 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine
Website: https://www.mdpi.com/journal/kidneydial

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