Lipidation of Class IV CdiA Effector Proteins Promotes Target Cell Recognition during Contact-Dependent Growth Inhibition

Tiffany M. Halvorsen; Fernando Garza-Sánchez; Zachary C. Ruhe; Nicholas L. Bartelli; Nicole A. Chan; Josephine Y. Nguyen; David A. Low; Christopher S. Hayes

doi:10.1128/mBio.02530-21

mBio (Oct 2021)

Lipidation of Class IV CdiA Effector Proteins Promotes Target Cell Recognition during Contact-Dependent Growth Inhibition

Tiffany M. Halvorsen,
Fernando Garza-Sánchez,
Zachary C. Ruhe,
Nicholas L. Bartelli,
Nicole A. Chan,
Josephine Y. Nguyen,
David A. Low,
Christopher S. Hayes

Affiliations

Tiffany M. Halvorsen: Biomolecular Science and Engineering, University of California, Santa Barbara, Santa Barbara, California, USA
Fernando Garza-Sánchez: Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA
Zachary C. Ruhe: Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA
Nicholas L. Bartelli: Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California, USA
Nicole A. Chan: Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA
Josephine Y. Nguyen: Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA
David A. Low: Biomolecular Science and Engineering, University of California, Santa Barbara, Santa Barbara, California, USA
Christopher S. Hayes: Biomolecular Science and Engineering, University of California, Santa Barbara, Santa Barbara, California, USA

DOI: https://doi.org/10.1128/mBio.02530-21
Journal volume & issue: Vol. 12, no. 5

Abstract

Read online

Contact-dependent growth inhibition (CDI) is a common form of interbacterial competition in which cells use CdiA effectors to deliver toxic proteins into their neighbors. CdiA recognizes target bacteria through specific receptor molecules on the cell surface.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal