mBio
(Oct 2021)
Lipidation of Class IV CdiA Effector Proteins Promotes Target Cell Recognition during Contact-Dependent Growth Inhibition
Tiffany M. Halvorsen,
Fernando Garza-Sánchez,
Zachary C. Ruhe,
Nicholas L. Bartelli,
Nicole A. Chan,
Josephine Y. Nguyen,
David A. Low,
Christopher S. Hayes
Affiliations
Tiffany M. Halvorsen
Biomolecular Science and Engineering, University of California, Santa Barbara, Santa Barbara, California, USA
Fernando Garza-Sánchez
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA
Zachary C. Ruhe
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA
Nicholas L. Bartelli
Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California, USA
Nicole A. Chan
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA
Josephine Y. Nguyen
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California, USA
David A. Low
Biomolecular Science and Engineering, University of California, Santa Barbara, Santa Barbara, California, USA
Christopher S. Hayes
Biomolecular Science and Engineering, University of California, Santa Barbara, Santa Barbara, California, USA
DOI
https://doi.org/10.1128/mBio.02530-21
Journal volume & issue
Vol. 12,
no. 5
Abstract
Read online
Contact-dependent growth inhibition (CDI) is a common form of interbacterial competition in which cells use CdiA effectors to deliver toxic proteins into their neighbors. CdiA recognizes target bacteria through specific receptor molecules on the cell surface.
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