Nature Communications (Aug 2020)

Cosmc controls B cell homing

  • Junwei Zeng,
  • Mahmoud Eljalby,
  • Rajindra P. Aryal,
  • Sylvain Lehoux,
  • Kathrin Stavenhagen,
  • Matthew R. Kudelka,
  • Yingchun Wang,
  • Jianmei Wang,
  • Tongzhong Ju,
  • Ulrich H. von Andrian,
  • Richard D. Cummings

DOI
https://doi.org/10.1038/s41467-020-17765-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Migration and homing of B cells to lymph nodes are important for B cell functions, but their regulation is poorly understood. Here, the authors show that B cell-specific deletion of Cosmc results in decreased protein O-glycosylation, loss of B cell homing to both lymphoid and nonlymphoid organs, and altered transendothelial migration implicated in this loss.