Molecules (Jun 2024)

Nanoparticles as Drug Delivery Systems for the Targeted Treatment of Atherosclerosis

  • Alexander Shao-Rong Pang,
  • Tarini Dinesh,
  • Natalie Yan-Lin Pang,
  • Vishalli Dinesh,
  • Kimberley Yun-Lin Pang,
  • Cai Ling Yong,
  • Shawn Jia Jun Lee,
  • George W. Yip,
  • Boon Huat Bay,
  • Dinesh Kumar Srinivasan

DOI
https://doi.org/10.3390/molecules29122873
Journal volume & issue
Vol. 29, no. 12
p. 2873

Abstract

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Atherosclerosis continues to be a leading cause of morbidity and mortality globally. The precise evaluation of the extent of an atherosclerotic plaque is essential for forecasting its likelihood of causing health concerns and tracking treatment outcomes. When compared to conventional methods used, nanoparticles offer clear benefits and excellent development opportunities for the detection and characterisation of susceptible atherosclerotic plaques. In this review, we analyse the recent advancements of nanoparticles as theranostics in the management of atherosclerosis, with an emphasis on applications in drug delivery. Furthermore, the main issues that must be resolved in order to advance clinical utility and future developments of NP research are discussed. It is anticipated that medical NPs will develop into complex and advanced next-generation nanobotics that can carry out a variety of functions in the bloodstream.

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