Diabetes, Metabolic Syndrome and Obesity (May 2023)
The Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy
Abstract
Huiling Chen,1,2 Xiaojing Huang,2 Meiyuan Dong,2 Song Wen,2 Ligang Zhou,2 Xinlu Yuan2 1Graduate School of Fudan University, Shanghai, People’s Republic of China; 2Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Xinlu Yuan, Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of China, Tel +8613370211617, Email [email protected]: Diabetes and sarcopenia are emerging as serious public health issues. Sarcopenia, an age-related disorder characterized by loss of skeletal muscle mass and function, is recognized as a new complication in elderly patients with type 2 diabetes mellitus (T2DM). Type 2 diabetes is characterized by insulin resistance, chronic inflammation, accumulation of advanced glycation products and increased oxidative stress, which can negatively affect skeletal muscle mass, strength and function leading to sarcopenia. There is a mutual interrelationship between T2DM and sarcopenia in light of pathophysiology mechanism and long-term outcome. T2DM will accelerate the decline of muscle mass and function, which will in turn lead to glucose metabolism disorders, reduced physical activity and the risk of diabetes. However, the specific mechanism involved has not been thoroughly studied. Therefore, this review aims to explore the pathophysiology and therapeutic strategy related to sarcopenia and diabetes and provide insight for future investigations, which is of great significance for improving the quality of life in the elderly with diabetes and concurrently reducing the incidence of related complications.Keywords: type 2 diabetes mellitus, sarcopenia, insulin resistance, inflammation, gut microbiota, therapeutic strategy
