Nature Communications (Mar 2021)
Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
- Anthony M. Cadena,
- John D. Ventura,
- Peter Abbink,
- Erica N. Borducchi,
- Hubert Tuyishime,
- Noe B. Mercado,
- Victoria Walker-Sperling,
- Mazuba Siamatu,
- Po-Ting Liu,
- Abishek Chandrashekar,
- Joseph P. Nkolola,
- Katherine McMahan,
- Nicole Kordana,
- Venous Hamza,
- Esther A. Bondzie,
- Emily Fray,
- Mithra Kumar,
- Stephanie Fischinger,
- Sally A. Shin,
- Mark G. Lewis,
- Robert F. Siliciano,
- Galit Alter,
- Dan H. Barouch
Affiliations
- Anthony M. Cadena
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- John D. Ventura
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Peter Abbink
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Erica N. Borducchi
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Hubert Tuyishime
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Noe B. Mercado
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Victoria Walker-Sperling
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Mazuba Siamatu
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Po-Ting Liu
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Abishek Chandrashekar
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Joseph P. Nkolola
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Katherine McMahan
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Nicole Kordana
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Venous Hamza
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Esther A. Bondzie
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Emily Fray
- Department of Medicine, Johns Hopkins University School of Medicine
- Mithra Kumar
- Department of Medicine, Johns Hopkins University School of Medicine
- Stephanie Fischinger
- Ragon Institute of MGH, MIT, and Harvard
- Sally A. Shin
- Ragon Institute of MGH, MIT, and Harvard
- Mark G. Lewis
- Bioqual
- Robert F. Siliciano
- Department of Medicine, Johns Hopkins University School of Medicine
- Galit Alter
- Ragon Institute of MGH, MIT, and Harvard
- Dan H. Barouch
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-021-21724-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
The existence of HIV reservoir and ongoing replication despite antiretroviral therapy (ART) represents a barrier for cure efforts. Here, using SIV/SHIV-infected rhesus macaque suppressed with ART for one year, the authors characterize multiple lymphoid and non-lymphoid tissues and show that while the viral reservoir exhibits a wide anatomic heterogeneity, persistent viral transcription is mainly restricted to secondary lymphoid organs.
