Health Technology Assessment in Action (Dec 2021)
A Safety and Efficacy of Stem Cell Therapeutics in Wound Healing: A Rapid Review of Available Evidence
Abstract
Context: skin and wound health a serious public health problem with high morbidity and mortality rates worldwide. Although there are different treatment options presented, there is no agreement on the best treatment for severe burns and wound problems as of yet. Stem cell therapy has a bright prospect in many preclinical studies of burn wounds. The rapid review was performed to assess the efficacy and possible mechanisms of stem cells in wound healing. Methods: This is a rapid review of the evidence for the potential effects of stem cell on wound healing, which intended to create a policy guide. To do so, health technology assessment studies indexed in PubMed, Scopus and Scholar on March 13, 2021 were searched using the keywords, including stem cell effects and wound healing. In addition, references of recovered studies were checked to ensure through the capture of the literature. Studies on the safety and efficacy of stem cell on wound healing, both in Persian or English, were included. Results: In total 92 titles were identified, which after eliminating duplicates and applying inclusion criteria, 22 were included. The overall review showed that stem cell therapy improved wound but more study is needed though it is promising. Also, studies showed using stem cell technology as a non-invasive way can be a good alternative to older treatments. Finally, Restrictions of this technology may include the need to improve cell delivery methods, cell viability, heterogeneity in the preparation of mesenchymal stem cells, and wound substrate. Further studies may be needed to determine its safety and efficiency. Conclusions: Evidence on the safety and efficacy of stem cell on wound were very limited to make a decision but Studies showed that stem cell technology is a good alternative to traditional therapies. These findings also demonstrate the need for considering variations in future clinical studies using stem cells to treat a burn wound in order to maximize the effectiveness.
