Nature Communications (Dec 2017)
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques
- Benjamin J. Burwitz,
- Jochen M. Wettengel,
- Martin A. Mück-Häusl,
- Marc Ringelhan,
- Chunkyu Ko,
- Marvin M. Festag,
- Katherine B. Hammond,
- Mina Northrup,
- Benjamin N. Bimber,
- Thomas Jacob,
- Jason S. Reed,
- Reed Norris,
- Byung Park,
- Sven Moller-Tank,
- Knud Esser,
- Justin M. Greene,
- Helen L. Wu,
- Shaheed Abdulhaqq,
- Gabriela Webb,
- William F. Sutton,
- Alex Klug,
- Tonya Swanson,
- Alfred W. Legasse,
- Tania Q. Vu,
- Aravind Asokan,
- Nancy L. Haigwood,
- Ulrike Protzer,
- Jonah B. Sacha
Affiliations
- Benjamin J. Burwitz
- Vaccine and Gene Therapy Institute, Oregon Health and Science University
- Jochen M. Wettengel
- Institute of Virology, Technical University of Munich/Helmholtz Zentrum Munich
- Martin A. Mück-Häusl
- Institute of Virology, Technical University of Munich/Helmholtz Zentrum Munich
- Marc Ringelhan
- Institute of Virology, Technical University of Munich/Helmholtz Zentrum Munich
- Chunkyu Ko
- Institute of Virology, Technical University of Munich/Helmholtz Zentrum Munich
- Marvin M. Festag
- Institute of Virology, Technical University of Munich/Helmholtz Zentrum Munich
- Katherine B. Hammond
- Vaccine and Gene Therapy Institute, Oregon Health and Science University
- Mina Northrup
- Vaccine and Gene Therapy Institute, Oregon Health and Science University
- Benjamin N. Bimber
- Oregon National Primate Research Center, Oregon Health and Science University
- Thomas Jacob
- Department of Biomedical Engineering, Oregon Health and Science University
- Jason S. Reed
- Vaccine and Gene Therapy Institute, Oregon Health and Science University
- Reed Norris
- Oregon National Primate Research Center, Oregon Health and Science University
- Byung Park
- Public Health and Preventative Medicine, Oregon Health and Science University
- Sven Moller-Tank
- Gene Therapy Center, The University of North Carolina at Chapel Hill
- Knud Esser
- Institute of Virology, Technical University of Munich/Helmholtz Zentrum Munich
- Justin M. Greene
- Vaccine and Gene Therapy Institute, Oregon Health and Science University
- Helen L. Wu
- Vaccine and Gene Therapy Institute, Oregon Health and Science University
- Shaheed Abdulhaqq
- Vaccine and Gene Therapy Institute, Oregon Health and Science University
- Gabriela Webb
- Vaccine and Gene Therapy Institute, Oregon Health and Science University
- William F. Sutton
- Oregon National Primate Research Center, Oregon Health and Science University
- Alex Klug
- Oregon National Primate Research Center, Oregon Health and Science University
- Tonya Swanson
- Oregon National Primate Research Center, Oregon Health and Science University
- Alfred W. Legasse
- Oregon National Primate Research Center, Oregon Health and Science University
- Tania Q. Vu
- Department of Biomedical Engineering, Oregon Health and Science University
- Aravind Asokan
- Gene Therapy Center, The University of North Carolina at Chapel Hill
- Nancy L. Haigwood
- Oregon National Primate Research Center, Oregon Health and Science University
- Ulrike Protzer
- Institute of Virology, Technical University of Munich/Helmholtz Zentrum Munich
- Jonah B. Sacha
- Vaccine and Gene Therapy Institute, Oregon Health and Science University
- DOI
- https://doi.org/10.1038/s41467-017-01953-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggesting this as animal model for future HBV studies.
