Glucose transporters: Important regulators of endometrial cancer therapy sensitivity

Xing Zhang; Xing Zhang; Jia-Jing Lu; Ayitila Abudukeyoumu; Ding-Yu Hou; Jing Dong; Jiang-Nan Wu; Li-Bing Liu; Ming-Qing Li; Ming-Qing Li; Ming-Qing Li; Feng Xie

doi:10.3389/fonc.2022.933827

Frontiers in Oncology (Aug 2022)

Glucose transporters: Important regulators of endometrial cancer therapy sensitivity

Xing Zhang,
Xing Zhang,
Jia-Jing Lu,
Ayitila Abudukeyoumu,
Ding-Yu Hou,
Jing Dong,
Jiang-Nan Wu,
Li-Bing Liu,
Ming-Qing Li,
Ming-Qing Li,
Ming-Qing Li,
Feng Xie

Affiliations

Xing Zhang: Medical Center of Diagnosis and Treatment for Cervical and Intrauterine Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
Xing Zhang: Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, China
Jia-Jing Lu: Department of Gynecology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, China
Ayitila Abudukeyoumu: Department of Gynecology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, China
Ding-Yu Hou: Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, China
Jing Dong: Medical Center of Diagnosis and Treatment for Cervical and Intrauterine Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
Jiang-Nan Wu: Clinical Epidemiology, Clinical Research Center, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
Li-Bing Liu: Department of Gynecology, Changzhou No. 2 People’s Hospital, affiliated with Nanjing Medical University, Changzhou, China
Ming-Qing Li: Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, China
Ming-Qing Li: National Health Commission (NHC) Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, Shanghai, China
Ming-Qing Li: Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, China
Feng Xie: Medical Center of Diagnosis and Treatment for Cervical and Intrauterine Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China

DOI: https://doi.org/10.3389/fonc.2022.933827
Journal volume & issue: Vol. 12

Abstract

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Glucose is of great importance in cancer cellular metabolism. Working together with several glucose transporters (GLUTs), it provides enough energy for biological growth. The main glucose transporters in endometrial cancer (EC) are Class 1 (GLUTs 1–4) and Class 3 (GLUTs 6 and 8), and the overexpression of these GLUTs has been observed. Apart from providing abundant glucose uptake, these highly expressed GLUTs also participate in the activation of many crucial signaling pathways concerning the proliferation, angiogenesis, and metastasis of EC. In addition, overexpressed GLUTs may also cause endometrial cancer cells (ECCs) to be insensitive to hormone therapy or even resistant to radiotherapy and chemoradiotherapy. Therefore, GLUT inhibitors may hopefully become a sensitizer for EC precision-targeted therapies. This review aims to summarize the expression regulation, function, and therapy sensitivity of GLUTs in ECCs, aiming to provide a new clue for better diagnosis and treatment of EC.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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