DegP Initiates Regulated Processing of Filamentous Hemagglutinin in Bordetella bronchiseptica

Abstract

Two-partner secretion (TPS) systems are broadly distributed among Gram-negative bacteria and play important roles in bacterial pathogenesis. FhaB-FhaC is the prototypical member of the TPS family and we here identified the protease that initiates a processing cascade that controls FhaB function.