Nature Communications (Jan 2022)
Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast
- Qianqian Shi,
- Kang Shao,
- Hongqin Jia,
- Boyang Cao,
- Weidong Li,
- Shichen Dong,
- Jian Liu,
- Kailiang Wu,
- Meng Liu,
- Fangfang Liu,
- Hanlin Zhou,
- Jianke Lv,
- Feng Gu,
- Luyuan Li,
- Shida Zhu,
- Shuai Li,
- Guibo Li,
- Li Fu
Affiliations
- Qianqian Shi
- Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital
- Kang Shao
- BGI-Shenzhen
- Hongqin Jia
- Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital
- Boyang Cao
- BGI-Shenzhen
- Weidong Li
- Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital
- Shichen Dong
- BGI-Shenzhen
- Jian Liu
- Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital
- Kailiang Wu
- Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital
- Meng Liu
- BGI-Shenzhen
- Fangfang Liu
- Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital
- Hanlin Zhou
- BGI-Shenzhen
- Jianke Lv
- Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital
- Feng Gu
- Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital
- Luyuan Li
- State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University
- Shida Zhu
- BGI-Shenzhen
- Shuai Li
- Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital
- Guibo Li
- BGI-Shenzhen
- Li Fu
- Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital
- DOI
- https://doi.org/10.1038/s41467-021-27794-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Invasive micropapillary carcinoma (IMPC) is a highly metastatic rare form of breast cancer but its genomic alterations are largely unknown. Here, the authors show that monoclonal metastatic ancestors share copy-number loss of PRDM16 and IGSF9 and gain of ALDH2 in primary samples from IMPC patients.
