Highly branched  poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells

Shuai Liu; Yongsheng Gao; Dezhong Zhou; Ming Zeng; Fatma Alshehri; Ben Newland; Jing Lyu; Jonathan O’Keeffe-Ahern; Udo Greiser; Tianying Guo; Fengzhi Zhang; Wenxin Wang

doi:10.1038/s41467-019-11190-0

Nature Communications (Jul 2019)

Highly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells

Shuai Liu,
Yongsheng Gao,
Dezhong Zhou,
Ming Zeng,
Fatma Alshehri,
Ben Newland,
Jing Lyu,
Jonathan O’Keeffe-Ahern,
Udo Greiser,
Tianying Guo,
Fengzhi Zhang,
Wenxin Wang

Affiliations

Shuai Liu: Charles Institute of Dermatology, School of Medicine, University College Dublin
Yongsheng Gao: Charles Institute of Dermatology, School of Medicine, University College Dublin
Dezhong Zhou: Charles Institute of Dermatology, School of Medicine, University College Dublin
Ming Zeng: Charles Institute of Dermatology, School of Medicine, University College Dublin
Fatma Alshehri: Charles Institute of Dermatology, School of Medicine, University College Dublin
Ben Newland: School of Pharmacy and Pharmaceutical Sciences, Cardiff University
Jing Lyu: Charles Institute of Dermatology, School of Medicine, University College Dublin
Jonathan O’Keeffe-Ahern: Charles Institute of Dermatology, School of Medicine, University College Dublin
Udo Greiser: Charles Institute of Dermatology, School of Medicine, University College Dublin
Tianying Guo: Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University
Fengzhi Zhang: School of Pharmaceutical Science, Zhejiang University of Technology
Wenxin Wang: Charles Institute of Dermatology, School of Medicine, University College Dublin

DOI: https://doi.org/10.1038/s41467-019-11190-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Therapeutics delivery by using non-viral vectors presents several challenges in the design of an appropriate polymeric structure. Here, the authors report a series of highly branched, biodegradable polymers which show high transfection efficiency in human multipotent adipose derived stem cells and primary astrocytes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal