Assessing Biocompatibility of Composite Cements by Peri/Intramuscular and Subcutaneous Implantation in Rats
Alina Ioana Ardelean,
Sorin Marian Marza,
Andrada Negoescu,
Madalina Florina Dragomir,
Codruta Sarosi,
Marioara Moldovan,
Razvan Ene,
Liviu Oana
Affiliations
Alina Ioana Ardelean
Department of Veterinary Surgery, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 400372 Cluj-Napoca, Romania
Sorin Marian Marza
Department of Veterinary Imagistics, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 400372 Cluj-Napoca, Romania
Andrada Negoescu
Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 400372 Cluj-Napoca, Romania
Madalina Florina Dragomir
Department of Veterinary Surgery, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 400372 Cluj-Napoca, Romania
Codruta Sarosi
Department Polymeric Composites, Babeș-Bolyai University, 400294 Cluj-Napoca, Romania
Marioara Moldovan
Department Polymeric Composites, Babeș-Bolyai University, 400294 Cluj-Napoca, Romania
Razvan Ene
Department Orthopedics, Anesthesia and Intensive Care, University of Medicine and Pharmacy “Carol Davila”, 020021 Bucharest, Romania
Liviu Oana
Department of Veterinary Surgery, Faculty of Veterinary Medicine, University of Agricultura Sciencies and Veterinary Medicine, 400372 Cluj-Napoca, Romania
This study’s goal was to evaluate the biocompatibility of two composite cements over a 90-day period by analyzing the individuals’ behavior as well as conducting macroscopic and histological examinations and Computed Tomography (CT) scans. We conducted the cytotoxicity test by placing the materials subcutaneously and peri/intramuscularly. Days 30 and 90 were crucial for our research. On those days, we harvested the implants, kidneys and liver to search for any toxic deposits. The biomaterial’s uniformity, color and texture remained unaltered despite being in intimate contact with the tissue. Although a slight inflammatory response was observed in the placement location, we observed an improved outcome of the interaction between the material and its insertion area. There were no notable discoveries in the liver and kidneys. According to the obtained results, the biomaterials did not produce any clinical changes nor specific irritation during the research, demonstrating that they are biocompatible with biological tissues.
