Prognostic value of red blood cell distribution width combined with chloride in predicting short- and long-term mortality in critically ill patients with congestive heart failure: Findings from the MIMIC-IV database

Chong Zhang; Tian-hua Hou; Wei-ru Liang; Cui-jun Hao; Fei Wang; Jia-yan Xin; Bin Su; Meng Ning; Ying-wu Liu

Heliyon (Jan 2024)

Prognostic value of red blood cell distribution width combined with chloride in predicting short- and long-term mortality in critically ill patients with congestive heart failure: Findings from the MIMIC-IV database

Chong Zhang,
Tian-hua Hou,
Wei-ru Liang,
Cui-jun Hao,
Fei Wang,
Jia-yan Xin,
Bin Su,
Meng Ning,
Ying-wu Liu

Affiliations

Chong Zhang: The Third Central Clinical College of Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China; Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin, China
Tian-hua Hou: The Third Central Clinical College of Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China; Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin, China
Wei-ru Liang: State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
Cui-jun Hao: The Third Central Clinical College of Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China; Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin, China
Fei Wang: The Third Central Clinical College of Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China; Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin, China
Jia-yan Xin: The Third Central Clinical College of Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China; Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin, China
Bin Su: The Third Central Clinical College of Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China; Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin, China
Meng Ning: Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China; Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin, China
Ying-wu Liu: The Third Central Clinical College of Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, The Third Central Hospital of Tianjin, Tianjin, China; Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin, China; Tianjin Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China; Department of Heart Center, The Third Central Hospital of Tianjin, Tianjin, China; Corresponding author. The Third Central Clinical College of Tianjin Medical University. Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Department of Heart Center, The Third Central Hospital of Tianjin, No. 83 Jintang Road, Hedong District, Tianjin, 300170, China.

Journal volume & issue: Vol. 10, no. 1
p. e23353

Abstract

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Background: Hypochloremia and red blood cell distribution width (RDW) play important roles in congestive heart failure (CHF) pathophysiology, and they were associated with the prognosis of CHF. However, the prognostic value of chloride combined with RDW in patients with CHF remains unknown. Methods: We retrospectively analyzed critically ill patients with CHF. The database was derived from the Medical Information Mart for Intensive Care IV v2.0 (MIMIC-IV-v2.0) database. Results: In the final analysis, 5376 critically ill patients with CHF were included, and 2428 patients (45.2 %) experienced 5-year mortality. The restricted cubic spline model revealed a positive correlation between RDW and 5-year mortality, whereas chloride showed a U-shaped correlation with 5-year mortality. The median values of RDW and chloride were used to classify patients into four groups: high chloride/low RDW, low chloride/low RDW, high chloride/high RDW, and low chloride/high RDW. We observed the prognostic value of RDW combined with chloride in the Cox proportional hazard model, in predicting 5-year mortality, in-hospital mortality and 1-year mortality. Furthermore, we discovered that patients with chronic kidney disease (CKD) had a higher 5-year mortality risk than patients without CKD. Conclusion: We found the translational potential role of chloride combined with RDW in prioritizing patients at high risk for short- and long-term mortality in a cohort of critically ill patients with CHF. Prospective multicenter investigations are warranted to validate our results.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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