Frontiers in Neuroscience (Jun 2021)

Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons

  • Onuralp Karatum,
  • Mohammad Mohammadi Aria,
  • Guncem Ozgun Eren,
  • Erdost Yildiz,
  • Rustamzhon Melikov,
  • Shashi Bhushan Srivastava,
  • Saliha Surme,
  • Itir Bakis Dogru,
  • Houman Bahmani Jalali,
  • Burak Ulgut,
  • Afsun Sahin,
  • Afsun Sahin,
  • Ibrahim Halil Kavakli,
  • Sedat Nizamoglu,
  • Sedat Nizamoglu

Journal volume & issue
Vol. 15


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Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (∼0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.