College of Grassland Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China; Institute of Ecological and Environmental Sciences, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China; Department of Chemical and Petroleum Engineering, Schulich School of Engineering, the University of Calgary, Calgary T2N 4H9, Canada
Jinxiang Hua
Institute of Ecological and Environmental Sciences, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China
Jinguang Hu
Department of Chemical and Petroleum Engineering, Schulich School of Engineering, the University of Calgary, Calgary T2N 4H9, Canada
Li Zhao
Institute of Ecological and Environmental Sciences, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China
Mei Huang
Institute of Ecological and Environmental Sciences, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China
Dong Tian
Institute of Ecological and Environmental Sciences, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China
Yongmei Zeng
Institute of Ecological and Environmental Sciences, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China
Shihuai Deng
Institute of Ecological and Environmental Sciences, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China
Fei Shen
Institute of Ecological and Environmental Sciences, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China
Xinquan Zhang
College of Grassland Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, P. R. China
Phosphoric acid-hydrogen peroxide (PHP) pretreatment is an effective method to obtain a cellulose-enriched fraction from biomass. In this study, artificial neural network (ANN) was used to predict PHP pretreatment efficiency of cellulose content (C-C), cellulose recovery (C-Ry), hemicellulose removal (H-Rl), and lignin removal (L-Rl) under various conditions of pretreatment time (t), temperature (T), H3PO4 concentration (Cp), and H2O2 concentration (Ch). The final optimized topology structure of the ANN models had 1 hidden layers with 9 neurons for C-C and 10 neurons for C-Ry, 10 neurons for H-Rl, and 12 neurons for L-Rl. The actual testing data fit the predicted data with R2 values ranging from 0.8070 to 0.9989. The relative importance (RI) revealed that Cp and Ch were significant factors influencing the efficiency of PHP pretreatment with total RI values ranging from 12% to 62.6%. However, their weights for the three components of biomass were different. The value of T dominated hemicellulose removal effectiveness with an RI value of 78.6%, while t did not seem to be a main factor dominating PHP pretreatment efficiency. The results of this study provide insights into the convenient development and optimization of biomass pretreatment from ANN modeling perspectives.