Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

Timothy James Kendall; Catherine Mary Duff; Luke Boulter; David H. Wilson; Elisabeth Freyer; Stuart Aitken; Stuart John Forbes; John Peter Iredale; Nicholas Dixon Hastie

doi:10.1038/s41467-019-12701-9

Nature Communications (Oct 2019)

Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

Timothy James Kendall,
Catherine Mary Duff,
Luke Boulter,
David H. Wilson,
Elisabeth Freyer,
Stuart Aitken,
Stuart John Forbes,
John Peter Iredale,
Nicholas Dixon Hastie

Affiliations

Timothy James Kendall: MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh
Catherine Mary Duff: MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh
Luke Boulter: MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh
David H. Wilson: MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh
Elisabeth Freyer: MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh
Stuart Aitken: MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh
Stuart John Forbes: MRC Centre for Regenerative Medicine, The University of Edinburgh
John Peter Iredale: University of Edinburgh Centre for Inflammation Research, The University of Edinburgh
Nicholas Dixon Hastie: MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh

DOI: https://doi.org/10.1038/s41467-019-12701-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 18

Abstract

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Activated hepatic stellate cells of putative mesodermal origin orchestrate scarring during injury. Here, the authors define a discrete morphologically plastic lineage of embryonic mesothelial-derived scar-orchestrating cells, through a distinct quiescent adult precursor, defined and paradoxically inhibited by WT1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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