Serinol-Based Versatile Disulfide-Reducing Reagent

Babita Kushwaha; Sinenhlanhla N. Mthembu; Anamika Sharma; Fernando Albericio; Beatriz G. de la Torre

doi:10.3390/molecules28145489

Molecules (Jul 2023)

Serinol-Based Versatile Disulfide-Reducing Reagent

Babita Kushwaha,
Sinenhlanhla N. Mthembu,
Anamika Sharma,
Fernando Albericio,
Beatriz G. de la Torre

Affiliations

Babita Kushwaha: KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa
Sinenhlanhla N. Mthembu: KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa
Anamika Sharma: KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa
Fernando Albericio: Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4000, South Africa
Beatriz G. de la Torre: KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa

DOI: https://doi.org/10.3390/molecules28145489
Journal volume & issue: Vol. 28, no. 14
p. 5489

Abstract

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Here, we report the synthesis of disulfide-reducing agents 2-(dibenzylamino) propane-1,3-dithiol (DPDT) and 2-(dibenzylamino)-2-methylpropane-1,3-dithiol (DMPDT) from serinol and methyl serinol, respectively. DPDT was found to show greater stability than DMPDT. Hence, the effectiveness of DPDT as a reducing agent was evaluated in both liquid and solid phases. The reducing capacity of this agent was comparable to that of DTT.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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