Microorganisms (Feb 2024)

Antiherpetic Activity of a Root Exudate from <i>Solanum lycopersicum</i>

  • Greta Bajetto,
  • Davide Arnodo,
  • Matteo Biolatti,
  • Linda Trifirò,
  • Camilla Albano,
  • Selina Pasquero,
  • Francesca Gugliesi,
  • Eva Campo,
  • Francesca Spyrakis,
  • Cristina Prandi,
  • Marco De Andrea,
  • Valentina Dell’Oste,
  • Ivan Visentin,
  • Marco Blangetti

DOI
https://doi.org/10.3390/microorganisms12020373
Journal volume & issue
Vol. 12, no. 2
p. 373

Abstract

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The rise of drug resistance to antivirals poses a significant global concern for public health; therefore, there is a pressing need to identify novel compounds that can effectively counteract strains resistant to current antiviral treatments. In light of this, researchers have been exploring new approaches, including the investigation of natural compounds as alternative sources for developing potent antiviral therapies. Thus, this work aimed to evaluate the antiviral properties of the organic-soluble fraction of a root exudate derived from the tomato plant Solanum lycopersicum in the context of herpesvirus infections. Our findings demonstrated that a root exudate from Solanum lycopersicum exhibits remarkable efficacy against prominent members of the family Herpesviridae, specifically herpes simplex virus type 1 (HSV-1) (EC50 25.57 µg/mL, SI > 15.64) and human cytomegalovirus (HCMV) (EC50 9.17 µg/mL, SI 32.28) by inhibiting a molecular event during the herpesvirus replication phase. Moreover, the phytochemical fingerprint of the Solanum lycopersicum root exudate was characterized through mass spectrometry. Overall, these data have unveiled a novel natural product with antiherpetic activity, presenting a promising and valuable alternative to existing drugs.

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