Physiological Implications of Prolonged Selenium Administrations in Normal and Desynchronized Adult Female Rats

Abstract

Background: Owing to the non-biodegradability of selenium, its prolonged consumption may lead to adverse health outcomes. Aim and Objectives: The study investigated the physiological effects of prolonged selenium administrations in normal and desynchronized rats. Material and Methods: Ninety six cyclical adult female rats were divided into short (1 week) and long (8 weeks) experimental cohort consisting of 6 groups each. Each experimental cohort contained control, High Selenium Dose (HSD) (150 μg/kg), Low Selenium Dose (LSD) (100 μg/kg), Desynchronized Group (AP), AP + HSD and AP + LSD. Results: In normal rats, HSD administration caused duration-dependent increase in ovarian PER1 expression and suprachiasmatic catalase and Glutathione Peroxidase (GPx) levels. LSD administration resulted in duration-dependent increase in Nocturnal Plasma Melatonin (NPM), ovarian PER1 expression, ovarian GPx and duration-dependent increase and decrease in nighttime temperature and ovarian catalase respectively. On the other hand, in AP rats, HSD administration resulted in durationdependent increase in ovarian PER1, NPM and suprachiasmatic catalase and duration-dependent decrease in nocturnal plasma glucose and ovarian catalase respectively. Also, LSD administration led to duration-dependent decrease in ovarian GPX and increase in ovarian PER1, suprachiasmatic GPX and catalase levels respectively. Conclusion: In normal rats, 8-week administration of 150 μg/kg of selenium relatively improved ovarian PER1 expression and glutathione peroxidase and catalase levels in suprachiasmatic nucleus. Prolonged selenium administrations caused beneficial effects in desynchronized rats.

Keywords

• desynchronized
• selenium
• antiperoxidative activity
• nocturnal plasma melatonin