GENETIC PREDICTORS OF IDIOPATHIC SICK SINUS SYNDROME

Abstract

Published data demonstrating genetic determination of sick sinus syndrome is presented. The definition of this pathology is presented; the main symptoms are described, as well as genes that influence the development of idiopathic sick sinus syndrome, their polymorphisms and role in disorders of the cardiovascular system.

Keywords

• idiopathic sinus syndrome
• genetic determinism
• myosin heavy chains (myh6) gene
• scn5a
• hcn4
• konneksin-40
• adra2b gene
• endothelial no-synthase gene