Diabetes, Metabolic Syndrome and Obesity (Jul 2022)

Association Between Serum Albumin Level and Microvascular Complications of Type 2 Diabetes Mellitus

  • Zhang J,
  • Deng Y,
  • Wan Y,
  • He S,
  • Cai W,
  • Xu J

Journal volume & issue
Vol. Volume 15
pp. 2173 – 2182

Abstract

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Jie Zhang,1 Yuanyuan Deng,1 Yang Wan,1 Shasha He,1 Wei Cai,2 Jixiong Xu1,3,4 1Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 2Department of Medical Genetics and Cell Biology, Medical College of Nanchang University, Nanchang, 330006, People’s Republic of China; 3Jiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, Jiangxi, 330006, People’s Republic of China; 4Jiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, Jiangxi, 330006, People’s Republic of ChinaCorrespondence: Jixiong Xu, Email [email protected]: To analyze the associations between serum albumin (sALB) level and diabetic microvascular complications, including diabetic retinopathy (DR) and diabetic kidney disease (DKD), in patients with type 2 diabetes mellitus (T2DM).Methods: This retrospective study included 951 hospitalized patients with T2DM who had completed screening for DR and DKD during hospitalization. Patients were divided into three groups according to sALB tertiles. Multivariate logistic regression analysis was used to assess the association of sALB with microvascular complications.Results: The prevalence of DR, DKD and macroalbuminuria increased with decreasing sALB levels. Multivariate logistic regression analysis showed that lower levels of sALB (Q1) were associated with higher risk of DR (odds ratio [OR]: 1.59, 95% confidence interval [CI]: 1.12– 2.26), DKD (OR: 3.00, 95% CI: 2.04– 4.41) and macroalbuminuria (OR: 9.76, 95% CI: 4.62– 20.63) compared with higher levels of sALB (Q3) after adjustment for other risk factors. After stratification by sex and age, the effect of lower levels of sALB (Q1) on DR incidence was more obvious in patients with male (OR: 1.60, 95% CI: 1.00– 2.56), and aged< 65 years (OR: 1.74, 95% CI: 1.14– 2.65) (P

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