Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective

Zhenyi An; Wei-Chung Chiang; Álvaro F. Fernández; Luis H. Franco; CongCong He; Shu-Yi Huang; Eunmyong Lee; Yang Liu; Salwa Sebti; Sanae Shoji-Kawata; Shyam Sirasanagandla; Richard C. Wang; Yongjie Wei; Yuting Zhao; Silvia Vega-Rubin-de-Celis

doi:10.3389/fcell.2022.891332

Frontiers in Cell and Developmental Biology (Jun 2022)

Beth Levine’s Legacy: From the Discovery of BECN1 to Therapies. A Mentees’ Perspective

Zhenyi An,
Wei-Chung Chiang,
Álvaro F. Fernández,
Luis H. Franco,
CongCong He,
Shu-Yi Huang,
Eunmyong Lee,
Yang Liu,
Salwa Sebti,
Sanae Shoji-Kawata,
Shyam Sirasanagandla,
Richard C. Wang,
Yongjie Wei,
Yuting Zhao,
Silvia Vega-Rubin-de-Celis

Affiliations

Zhenyi An: Broad Institute of MIT and Harvard, Cambridge, MA, United States
Wei-Chung Chiang: Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
Álvaro F. Fernández: Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
Luis H. Franco: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
CongCong He: Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States
Shu-Yi Huang: Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
Eunmyong Lee: InnoCure Therapeutics Inc., Gyeonggi-do, South Korea
Yang Liu: Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, United States
Salwa Sebti: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States
Sanae Shoji-Kawata: 0Department of Pharmacy, Nishi Nara Central Hospital, Nara, Japan
Shyam Sirasanagandla: 1St Jude Children’s Research Hospital, Memphis, TN, United States
Richard C. Wang: 2Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, United States
Yongjie Wei: 3Cancer Research Institute, Guangzhou Medical University, Guangzhou, China
Yuting Zhao: 4Institute of Future Agriculture, Northwest A&F University, Yangling, China
Silvia Vega-Rubin-de-Celis: 5Institute for Cell Biology (Cancer Research), Essen University Hospital, University of Duisburg-Essen, Essen, Germany

DOI: https://doi.org/10.3389/fcell.2022.891332
Journal volume & issue: Vol. 10

Abstract

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With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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