Benzylic C−H acylation by cooperative NHC and photoredox catalysis

Abstract

Direct acylation of sp3 C−H bonds in complex organic molecules is not well established compared to that of sp2 C−H bonds. Here, the authors report the combination of N-heterocyclic carbene (NHC) and photoredox catalysis for the direct and site-selective acylation of benzylic C−H bonds.