Haematologica (Nov 2007)

Association of transforming growth factor-β1 gene polymorphism in the development of Epstein-Barr virus-related hematologic diseases

  • Kanako Hatta,
  • Akira Morimoto,
  • Eiichi Ishii,
  • Hiroshi Kimura,
  • Ikuyo Ueda,
  • Shigeyoshi Hibi,
  • Shinjiro Todo,
  • Tohru Sugimoto,
  • Shinsaku Imashuku

DOI
https://doi.org/10.3324/haematol.11147
Journal volume & issue
Vol. 92, no. 11

Abstract

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Background and Objectives Epstein-Barr virus (EBV) is etiologically associated with various hematologic disorders, including primary acute infectious mononucleosis (IM), hemophagocytic lymphohistiocytosis (EBV-HLH), chronic active EBV infection (CAEBV) and malignant lymphomas. Although cytokines play a central role in EBV-related immune responses, the exact mechanisms causing different clinical responses remain unclear. In this study, the pattern of cytokine gene polymorphisms was comparatively analyzed in EBV-related diseases.Design and Methods Eighty-nine patients with EBV-related disease were analyzed; 30 with IM, 28 with EBV-HLH and 31 with CAEBV. Eighty-one EBV-seropositive healthy adults were also used as controls. Associations with polymorphisms of various cytokines, including interleukin (IL)-1α and IL-1β were evaluated. The gene polymorphisms were typed by polymerase chain reaction with sequence-specific primers.Results A significant difference of polymorphisms was found for transforming growth factor (TGF)-β1; the frequency of TGF-β1 codon 10 C allele was significantly higher in patients with EBV-related diseases than in controls (p