An ionizable lipid toolbox for RNA delivery

Xuexiang Han; Hanwen Zhang; Kamila Butowska; Kelsey L. Swingle; Mohamad-Gabriel Alameh; Drew Weissman; Michael J. Mitchell

doi:10.1038/s41467-021-27493-0

Nature Communications (Dec 2021)

An ionizable lipid toolbox for RNA delivery

Xuexiang Han,
Hanwen Zhang,
Kamila Butowska,
Kelsey L. Swingle,
Mohamad-Gabriel Alameh,
Drew Weissman,
Michael J. Mitchell

Affiliations

Xuexiang Han: Department of Bioengineering, University of Pennsylvania
Hanwen Zhang: Department of Bioengineering, University of Pennsylvania
Kamila Butowska: Department of Bioengineering, University of Pennsylvania
Kelsey L. Swingle: Department of Bioengineering, University of Pennsylvania
Mohamad-Gabriel Alameh: Department of Medicine, University of Pennsylvania
Drew Weissman: Department of Medicine, University of Pennsylvania
Michael J. Mitchell: Department of Bioengineering, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-021-27493-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 6

Abstract

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RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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