Nature Communications (Oct 2017)
The driver landscape of sporadic chordoma
- Patrick S. Tarpey,
- Sam Behjati,
- Matthew D. Young,
- Inigo Martincorena,
- Ludmil B. Alexandrov,
- Sarah J. Farndon,
- Charlotte Guzzo,
- Claire Hardy,
- Calli Latimer,
- Adam P. Butler,
- Jon W. Teague,
- Adam Shlien,
- P. Andrew Futreal,
- Sohrab Shah,
- Ali Bashashati,
- Farzad Jamshidi,
- Torsten O. Nielsen,
- David Huntsman,
- Daniel Baumhoer,
- Sebastian Brandner,
- Jay Wunder,
- Brendan Dickson,
- Patricia Cogswell,
- Josh Sommer,
- Joanna J. Phillips,
- M. Fernanda Amary,
- Roberto Tirabosco,
- Nischalan Pillay,
- Stephen Yip,
- Michael R. Stratton,
- Adrienne M. Flanagan,
- Peter J. Campbell
Affiliations
- Patrick S. Tarpey
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Sam Behjati
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Matthew D. Young
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Inigo Martincorena
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Ludmil B. Alexandrov
- Los Alamos National Laboratory
- Sarah J. Farndon
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Charlotte Guzzo
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Claire Hardy
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Calli Latimer
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Adam P. Butler
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Jon W. Teague
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Adam Shlien
- Department of Paediatric Laboratory Medicine, The Hospital for Sick Children
- P. Andrew Futreal
- Department of Genomic Medicine, MD Anderson Cancer Center, University of Texas
- Sohrab Shah
- University of British Columbia
- Ali Bashashati
- University of British Columbia
- Farzad Jamshidi
- University of British Columbia
- Torsten O. Nielsen
- University of British Columbia
- David Huntsman
- University of British Columbia
- Daniel Baumhoer
- Bone Tumour Reference Centre, Institute of Pathology, University Hospital Basel, University of Basel
- Sebastian Brandner
- Division of Neuropathology and Department of Neurodegenerative Disease, The National Hospital for Neurology and Neurosurgery, University College Hospital NHS Foundation Trust and UCL Institute of Neurology
- Jay Wunder
- Department of Pathology and Laboratory Medicine, Mount Sinai Hospital
- Brendan Dickson
- Department of Pathology and Laboratory Medicine, Mount Sinai Hospital
- Patricia Cogswell
- Chordoma Foundation
- Josh Sommer
- Chordoma Foundation
- Joanna J. Phillips
- Department of Neurosurgery, University of California
- M. Fernanda Amary
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Roberto Tirabosco
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Nischalan Pillay
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Stephen Yip
- University of British Columbia
- Michael R. Stratton
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Adrienne M. Flanagan
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Peter J. Campbell
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- DOI
- https://doi.org/10.1038/s41467-017-01026-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 6
Abstract
Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations in LYST, a potential novel cancer gene in chordoma.
