Nature Communications (Sep 2022)
MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis
- Hiroki Takahashi,
- Ge Yang,
- Takeshi Yoneshiro,
- Yohei Abe,
- Ryo Ito,
- Chaoran Yang,
- Junna Nakazono,
- Mayumi Okamoto-Katsuyama,
- Aoi Uchida,
- Makoto Arai,
- Hitomi Jin,
- Hyunmi Choi,
- Myagmar Tumenjargal,
- Shiyu Xie,
- Ji Zhang,
- Hina Sagae,
- Yanan Zhao,
- Rei Yamaguchi,
- Yu Nomura,
- Yuichi Shimizu,
- Kaito Yamada,
- Satoshi Yasuda,
- Hiroshi Kimura,
- Toshiya Tanaka,
- Youichiro Wada,
- Tatsuhiko Kodama,
- Hiroyuki Aburatani,
- Min-Sheng Zhu,
- Takeshi Inagaki,
- Timothy F. Osborne,
- Takeshi Kawamura,
- Yasushi Ishihama,
- Yoshihiro Matsumura,
- Juro Sakai
Affiliations
- Hiroki Takahashi
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Ge Yang
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Takeshi Yoneshiro
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Yohei Abe
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Ryo Ito
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Chaoran Yang
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Junna Nakazono
- Department of Molecular and Cellular BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University
- Mayumi Okamoto-Katsuyama
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Aoi Uchida
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Makoto Arai
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Hitomi Jin
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Hyunmi Choi
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Myagmar Tumenjargal
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Shiyu Xie
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Ji Zhang
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Hina Sagae
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Yanan Zhao
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Rei Yamaguchi
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Yu Nomura
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Yuichi Shimizu
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Kaito Yamada
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Satoshi Yasuda
- Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
- Hiroshi Kimura
- Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology
- Toshiya Tanaka
- Department of Nuclear Receptor Medicine, Laboratories for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Youichiro Wada
- Isotope Science Center, The University of Tokyo
- Tatsuhiko Kodama
- Department of Nuclear Receptor Medicine, Laboratories for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Hiroyuki Aburatani
- Genome Science and Medicine Division, Research Center for Advanced Science and Technology, The University of Tokyo
- Min-Sheng Zhu
- Model Animal Research Center and Ministry of Education (MOE) Key Laboratory of Model Animal for Disease Study, Nanjing University
- Takeshi Inagaki
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo
- Timothy F. Osborne
- Institute for Fundamental Biomedical Research, Johns Hopkins All Children’s Hospital, and Medicine in the Division of Endocrinology, Diabetes and Metabolism of the Johns Hopkins University School of Medicine
- Takeshi Kawamura
- Isotope Science Center, The University of Tokyo
- Yasushi Ishihama
- Department of Molecular and Cellular BioAnalysis, Graduate School of Pharmaceutical Sciences, Kyoto University
- Yoshihiro Matsumura
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- Juro Sakai
- Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-33363-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
How β-AR signaling coordinates epigenetic and transcriptional pathways is unknown. Here the authors show that cold-induced β-AR signaling negatively regulates MYPT1-PP1β phosphatase activity to orchestrate both pathways for beige adipogenesis.
