Revista da Sociedade Brasileira de Medicina Tropical (Feb 2014)

Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection

  • Amanda Alves Fecury,
  • Marcella Kelly Costa de Almeida,
  • Kemper Nunes dos Santos,
  • Andrei da Silva Freitas,
  • Socorro de Fátima Loureiro Dantas,
  • Carlos Araújo da Costa,
  • Ângelo Barlleta Crescente,
  • Rita Catarina Medeiros de Sousa,
  • Elza Baía de Brito,
  • Reza Nassiri,
  • Elizabeth Lampe,
  • Luisa Caricio Martins

DOI
https://doi.org/10.1590/0037-8682-0008-2012
Journal volume & issue
Vol. 47, no. 1
pp. 90 – 92

Abstract

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Introduction: The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression. Methods: Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation. Results: Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis. Conclusions: HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction.

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