Communications Biology (May 2021)

Structural analysis of the SRP Alu domain from Plasmodium falciparum reveals a non-canonical open conformation

  • Komal Soni,
  • Georg Kempf,
  • Karen Manalastas-Cantos,
  • Astrid Hendricks,
  • Dirk Flemming,
  • Julien Guizetti,
  • Bernd Simon,
  • Friedrich Frischknecht,
  • Dmitri I. Svergun,
  • Klemens Wild,
  • Irmgard Sinning

DOI
https://doi.org/10.1038/s42003-021-02132-y
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 14

Abstract

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The SRP Alu domain is involved in co-translational protein targeting. Soni et al. investigate the Alu domain of Plasmodium falciparum, the agent of malaria, and find that unlike any other it adopts an open conformation.