Dermatology Reports (Jul 2010)

Taxane-induced morphea in a patient with CREST syndrome

  • Susan Michele Bouchard,
  • Melinda Mohr,
  • Robert Pariser

DOI
https://doi.org/10.4081/dr.2010.e9
Journal volume & issue
Vol. 2, no. 1
pp. e9 – e9

Abstract

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The taxanes, docetaxel and paclitaxel, are microtubule stabilizing chemotherapeutic agents that have demonstrated antineoplastic effects in a variety of solid tumors. They have been linked to the development of localized cutaneous sclerosis in some patients. We present a case of docetaxel-induced cutaneous sclerosis of the lower extremities in a patient with pre-existing CREST syndrome. We propose that patients with a history of limited or diffuse systemic sclerosis should be given taxane chemotherapy with caution, as these patients may have an immunological predisposition for the development of drug-induced morphea.

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