Nature Communications (Nov 2018)
miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC
- Young-Jun Jeon,
- Taewan Kim,
- Dongju Park,
- Gerard J. Nuovo,
- Siyeon Rhee,
- Pooja Joshi,
- Bum-Kyu Lee,
- Johan Jeong,
- Sung-suk Suh,
- Jeff E. Grotzke,
- Sung-Hak Kim,
- Jieun Song,
- Hosung Sim,
- Yonghwan Kim,
- Yong Peng,
- Youngtae Jeong,
- Michela Garofalo,
- Nicola Zanesi,
- Jonghwan Kim,
- Guang Liang,
- Ichiro Nakano,
- Peter Cresswell,
- Patrick Nana-Sinkam,
- Ri Cui,
- Carlo M. Croce
Affiliations
- Young-Jun Jeon
- Comprehensive Cancer Center, The Ohio State University
- Taewan Kim
- Comprehensive Cancer Center, The Ohio State University
- Dongju Park
- Comprehensive Cancer Center, The Ohio State University
- Gerard J. Nuovo
- Comprehensive Cancer Center, The Ohio State University
- Siyeon Rhee
- Department of Biology, Stanford University
- Pooja Joshi
- Comprehensive Cancer Center, The Ohio State University
- Bum-Kyu Lee
- Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, The University of Texas at Austin
- Johan Jeong
- Department of Pathology, Stanford University
- Sung-suk Suh
- Department of Biosciences, Mokpo National University
- Jeff E. Grotzke
- Departments of Immunobiology, Yale University School of Medicine
- Sung-Hak Kim
- Department of Animal Science, College of Agriculture and Life Sciences, Chonnam National University
- Jieun Song
- Comprehensive Cancer Center, The Ohio State University
- Hosung Sim
- Comprehensive Cancer Center, The Ohio State University
- Yonghwan Kim
- Department of Life System, Sookmyung Woman’s University
- Yong Peng
- Comprehensive Cancer Center, The Ohio State University
- Youngtae Jeong
- Stanford Cancer Institute, Stanford University School of Medicine
- Michela Garofalo
- Comprehensive Cancer Center, The Ohio State University
- Nicola Zanesi
- Department of Cancer Biology and Genetics, The Ohio State University
- Jonghwan Kim
- Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, The University of Texas at Austin
- Guang Liang
- School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou
- Ichiro Nakano
- Department of Neurosurgery UAB Comprehensive Cancer Center, University of Alabama at Birmingham
- Peter Cresswell
- Departments of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine
- Patrick Nana-Sinkam
- Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Medical Oncology, The Ohio State University
- Ri Cui
- Comprehensive Cancer Center, The Ohio State University
- Carlo M. Croce
- Comprehensive Cancer Center, The Ohio State University
- DOI
- https://doi.org/10.1038/s41467-018-07561-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
TUSC3 resides on chromosome 8p which is frequently deleted in advanced stage tumors. Here, the authors show that TUSC3 loss mediated by miR-224/-520c promotes NSCLC metastasis where it enhances ATF-6α-dependent UPR and HRD-1 dependent ERAD, which in turn suppress p53-NM23H1/2 tumor suppressor pathway.
