An information network flow approach for measuring functional connectivity and predicting behavior

Abstract

Abstract Introduction Connectome‐based predictive modeling (CPM) is a recently developed machine‐learning‐based framework to predict individual differences in behavior from functional brain connectivity (FC). In these models, FC was operationalized as Pearson's correlation between brain regions’ fMRI time courses. However, Pearson's correlation is limited since it only captures linear relationships. We developed a more generalized metric of FC based on information flow. This measure represents FC by abstracting the brain as a flow network of nodes that send bits of information to each other, where bits are quantified through an information theory statistic called transfer entropy. Methods With a sample of individuals performing a sustained attention task and resting during functional magnetic resonance imaging (fMRI) (n = 25), we use the CPM framework to build machine‐learning models that predict attention from FC patterns measured with information flow. Models trained on n − 1 participants’ task‐based patterns were applied to an unseen individual's resting‐state pattern to predict task performance. For further validation, we applied our model to two independent datasets that included resting‐state fMRI data and a measure of attention (Attention Network Task performance [n = 41] and stop‐signal task performance [n = 72]). Results Our model significantly predicted individual differences in attention task performance across three different datasets. Conclusions Information flow may be a useful complement to Pearson's correlation as a measure of FC because of its advantages for nonlinear analysis and network structure characterization.

Keywords

• functional connectivity
• information flow
• predictive model
• resting‐state fMRI connectivity
• sustained attention