Nature Communications (Jan 2016)
The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival
- Hiroto Ohguchi,
- Teru Hideshima,
- Manoj K. Bhasin,
- Gullu T. Gorgun,
- Loredana Santo,
- Michele Cea,
- Mehmet K. Samur,
- Naoya Mimura,
- Rikio Suzuki,
- Yu-Tzu Tai,
- Ruben D. Carrasco,
- Noopur Raje,
- Paul G. Richardson,
- Nikhil C. Munshi,
- Hideo Harigae,
- Takaomi Sanda,
- Juro Sakai,
- Kenneth C. Anderson
Affiliations
- Hiroto Ohguchi
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Teru Hideshima
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Manoj K. Bhasin
- BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center
- Gullu T. Gorgun
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Loredana Santo
- MGH Cancer Center, Massachusetts General Hospital
- Michele Cea
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Mehmet K. Samur
- Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute
- Naoya Mimura
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Rikio Suzuki
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Yu-Tzu Tai
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Ruben D. Carrasco
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Noopur Raje
- MGH Cancer Center, Massachusetts General Hospital
- Paul G. Richardson
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Nikhil C. Munshi
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Hideo Harigae
- Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine
- Takaomi Sanda
- Department of Medicine, Cancer Science Institute of Singapore, National University of Singapore
- Juro Sakai
- Division of Metabolic Medicine, Research Center for Advanced Science and Technology, University of Tokyo
- Kenneth C. Anderson
- Department of Medical Oncology, Dana-Farber Cancer Institute
- DOI
- https://doi.org/10.1038/ncomms10258
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Several histone modifiers have been implicated in the survival of multiple myeloma cells. Here, the authors reveal a role for the histone demethylase KDM3A in the survival of this haematologic cancer, and show that mechanistically KDM3A removes H3K9 methylation from the promoters of KLF2 and IRF4, genes essential for myeloma cell survival.
