Nature Communications (May 2022)
Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits
- Ananyo Choudhury,
- Jean-Tristan Brandenburg,
- Tinashe Chikowore,
- Dhriti Sengupta,
- Palwende Romuald Boua,
- Nigel J. Crowther,
- Godfred Agongo,
- Gershim Asiki,
- F. Xavier Gómez-Olivé,
- Isaac Kisiangani,
- Eric Maimela,
- Matshane Masemola-Maphutha,
- Lisa K. Micklesfield,
- Engelbert A. Nonterah,
- Shane A. Norris,
- Hermann Sorgho,
- Halidou Tinto,
- Stephen Tollman,
- Sarah E. Graham,
- Cristen J. Willer,
- AWI-Gen study,
- H3Africa Consortium,
- Scott Hazelhurst,
- Michèle Ramsay
Affiliations
- Ananyo Choudhury
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Jean-Tristan Brandenburg
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Tinashe Chikowore
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Dhriti Sengupta
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Palwende Romuald Boua
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Nigel J. Crowther
- Department of Chemical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand
- Godfred Agongo
- Navrongo Health Research Centre, Ghana Health Service
- Gershim Asiki
- African Population and Health Research Center
- F. Xavier Gómez-Olivé
- MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand
- Isaac Kisiangani
- African Population and Health Research Center
- Eric Maimela
- Department of Public Health, School of Health Care Sciences, Faculty of Health Sciences, University of Limpopo
- Matshane Masemola-Maphutha
- Department of Pathology and Medical Sciences, School of Health Care Sciences, Faculty of Health Sciences, University of Limpopo
- Lisa K. Micklesfield
- South African Medical Research Council/University of the Witwatersrand Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand
- Engelbert A. Nonterah
- Navrongo Health Research Centre, Ghana Health Service
- Shane A. Norris
- South African Medical Research Council/University of the Witwatersrand Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand
- Hermann Sorgho
- Clinical Research Unit of Nanoro, Institut de Recherche en Sciences de la Santè
- Halidou Tinto
- Clinical Research Unit of Nanoro, Institut de Recherche en Sciences de la Santè
- Stephen Tollman
- MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand
- Sarah E. Graham
- Department of Internal Medicine, Division of Cardiology, University of Michigan
- Cristen J. Willer
- Department of Internal Medicine, Division of Cardiology, University of Michigan
- AWI-Gen study
- H3Africa Consortium
- Scott Hazelhurst
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Michèle Ramsay
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- DOI
- https://doi.org/10.1038/s41467-022-30098-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Genetic associations and polygenic scores for lipid traits have low transferability to African individuals. Here, the authors perform a large sub-Sarahan African lipid GWAS and find that larger datasets and better global representation in discovery GWAS help to bridge this gap.
