Aromatic C-H addition of ketones to imines enabled by manganese catalysis

Bingwei Zhou; Yuanyuan Hu; Ting Liu; Congyang Wang

doi:10.1038/s41467-017-01262-4

Nature Communications (Oct 2017)

Aromatic C-H addition of ketones to imines enabled by manganese catalysis

Bingwei Zhou,
Yuanyuan Hu,
Ting Liu,
Congyang Wang

Affiliations

Bingwei Zhou: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences
Yuanyuan Hu: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences
Ting Liu: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences
Congyang Wang: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-017-01262-4
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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The Mannich reaction proceeds by functionalization of C(sp3)-H bonds alpha to carbonyls. Here, the authors suppress the Mannich reactivity of acetophenones in presence of a manganese catalyst and obtain valuable o-aminoalkylacetophenones and isoindolines via C(sp2)-H functionalization with imines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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